structure of lipoprotein
HDL has many good properties, including the inhibition of LDL oxidation and removal of cholesterol from cells, especially macrophages. presence of triacylglycerol, cholesteryl ester, free cholesterol, phospholipid, protein). Thus, the two-domain structure of apo E has been shown to lead to two different lipid-bound conformations on lipoprotein-like spherical particles. Lipoprotein Structure .
Cholesterol and triacylglycerols are transported in body fluids in the form of lipoprotein particles. HDL undergoes a reverse cholesterol transport where it retrieves cholesterol form other tissues in the body to return the excess/bad cholesterol to the liver for excretion. The more HDL, the more readily the transport of LDL and macrophages to liver occurs. The dynamic properties of the lipid monolayers depend largely on the nature of the constituent lipids. There are three main reasons for transport.
This review summarizes present knowledge of the structure, function, and genetics of Lp(a) with emphasis on the molecular and population genetics of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology.
J Intern Med. Human Genetics and the Causal Role of Lipoprotein(a) for Various Diseases. Receptor mutations disrupt almost every stage of the endocytosis pathway.
The only apoprotein associated with it is apoB-100. The percentage of short apo(a) isoforms (≤22 KIV-2 repeats) in 1,570 controls and 1,013 patients with myocardial infarction from six ethnic groups is shown. What is the role of Lipoproteins in the organism?
- Low-density lipoprotein (LDL): is the major carrier of cholesterol in blood.
This review summarizes present knowledge of the … The apo(a) allele-associated Lp(a) concentrations were determined in individuals from an African population (Gabonese Bantu) by measuring total Lp(a) concentrations by ELISA and assigning the appropriate fraction to each of the 194 alleles by densitometric evaluation of immunoblots. D: Both alleles have the same intra-allelic frequency (20%), though the number of copies carrying the variant is different. : +1 (217) 333-0452; Fax: +1 (217) 333-8868. The disease results from a mutation at a single autosomal locus and leads to higher than normal levels of cholesterol. The cholesteryl esters in LDL are hydrolyzed by a lysosomal acid lipase. Lipoprotein(a): an important cardiovascular risk factor and a clinical conundrum. 2020 Aug 4;12(8):2329. doi: 10.3390/nu12082329. Mendelian randomization; cardiovascular risk factor; copy number variation; lipoprotein metabolism.
2016 Feb;30(1):87-100. doi: 10.1007/s10557-016-6648-3.
Cardiovasc Drugs Ther. Data are from (24). Different scenarios for the…, Scheme illustrating the determination of…, Scheme illustrating the determination of Lp(a) plasma levels by LPA gene variation and…, Mendelian randomization approach to demonstrate…, Mendelian randomization approach to demonstrate a causal association between Lp(a) concentration and CHD.…, KIV-2 CNV and risk for CHD.
This chapter describes main lipoprotein classes, lipid components, apolipoproteins, and complexes of apolipoproteins with lipids. Although these classes of lipoproteins have many subtypes, these are the main classes that scientists have compiled based on density, diameter, and composition of various lipid components (i.e.
This chapter describes main lipoprotein classes, lipid components, apolipoproteins, and complexes of apolipoproteins with lipids. Clipboard, Search History, and several other advanced features are temporarily unavailable. eCollection 2020.
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